Differentiation in pyroptosis induction by Burkholderia pseudomallei and Burkholderia thailandensis in primary human monocytes, a possible cause of sepsis in acute melioidosis patients.

• Main Authors: Suphasuta Khongpraphan (Author), Peeraya Ekchariyawat (Author), Sucharat Sanongkiet (Author), Chularat Luangjindarat (Author), Stitaya Sirisinha (Author), Marisa Ponpuak (Author), Panuwat Midoeng (Author), Matsayapan Pudla (Author), Pongsak Utaisincharoen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melioidosis caused by Burkholderia pseudomallei is an infectious disease with a high mortality rate. In acute melioidosis, sepsis is a major cause of death among patients. Once the bacterium enters the bloodstream, immune system dysregulation ensues, leading to cytokine storms. In contrast to B. pse...