TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids

• Main Authors: Nan Wang (Author), Chenchen Si (Author), Lan Xia (Author), Xian Wu (Author), Sheng Zhao (Author), Huihui Xu (Author), Zhide Ding (Author), Zhihong Niu (Author)
• Format: Book
• Published: BMC, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Granulosa cells (GCs) in cumulus oophorus highly express follicle stimulating hormone receptor (FSHR), which is the most important mediator of both estradiol synthesis and oocyte maturation. Obese women have elevated free fatty acids (FFAs) levels in their follicular fluids and d...