Discovery of a potent olaparib-chlorambucil hybrid inhibitor of PARP1 for the treatment of cancer

Introduction: Development of Poly (ADP-ribose) polymerase (PARP) inhibitors has been extensively studied in cancer treatment. Olaparib, the first approved PARP inhibitor, showed potency in the inhibition of both BRCA (breast cancer associated)-mutated and BRCA-unmutated cancers.Methods: Aiming to th...

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Main Authors: Hongyu Qin (Author), Jian Zhang (Author), Yilu Zhao (Author), Lihui Zhang (Author), Jinhong Feng (Author), Lei Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
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3rd Floor Main Library

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