T cell epitope mapping of secukinumab and ixekizumab in healthy donors

• Main Authors: Sebastian Spindeldreher (Author), Anette Karle (Author), Evelyne Correia (Author), Maxime Tenon (Author), Sascha Gottlieb (Author), Thomas Huber (Author), Bernard Maillere (Author), Frank Kolbinger (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Secukinumab, a human monoclonal antibody that selectively neutralizes IL-17A, has consistently shown low anti-drug antibody responses in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis. Secukinumab has also shown lower in vitro immunogenicity potential compared with other mo...