Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies

• Main Authors: Dounia Sid (Author), Milad Baitiche (Author), Zineb Elbahri (Author), Ferhat Djerboua (Author), Mokhtar Boutahala (Author), Zouhair Bouaziz (Author), Marc Le Borgne (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with β-cyclodextrin (β-CD). First, the phase solubility diagram of MA in β-CD was drawn from 0 to 21 × 10−3 M of β-CD concentration. A job's plot experiment was used to de...