Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies

• Hauptverfasser: Dounia Sid (VerfasserIn), Milad Baitiche (VerfasserIn), Zineb Elbahri (VerfasserIn), Ferhat Djerboua (VerfasserIn), Mokhtar Boutahala (VerfasserIn), Zouhair Bouaziz (VerfasserIn), Marc Le Borgne (VerfasserIn)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Schlagworte: article
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The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with β-cyclodextrin (β-CD). First, the phase solubility diagram of MA in β-CD was drawn from 0 to 21 × 10−3 M of β-CD concentration. A job's plot experiment was used to de...