Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for Treatment of Lung Adenocarcinoma

• Main Authors: Shuai Guo (Author), Xue Bai (Author), Yufei Liu (Author), Sai Shi (Author), Xuzhao Wang (Author), Yong Zhan (Author), Xianjiang Kang (Author), Yafei Chen (Author), Hailong An (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed obvious antitumor efficacy.Methods: YFP fluorescenc...