Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.

• Main Authors: Gregory J Crowther (Author), Dhanasekaran Shanmugam (Author), Santiago J Carmona (Author), Maria A Doyle (Author), Christiane Hertz-Fowler (Author), Matthew Berriman (Author), Solomon Nwaka (Author), Stuart A Ralph (Author), David S Roos (Author), Wesley C Van Voorhis (Author), Fernán Agüero (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The increased sequencing of pathogen genomes and the subsequent availability of genome-scale functional datasets are expected to guide the experimental work necessary for target-based drug discovery. However, a major bottleneck in this has been the difficulty of capturing and integrating...