Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A

• Main Authors: Changyu Kang (Author), Jaejeong Kim (Author), Sanghyun Ju (Author), Heeyeong Cho (Author), Hyun Young Kim (Author), In-Soo Yoon (Author), Jin-Wook Yoo (Author), Yunjin Jung (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We designed colon-targeted trans-cinnamic acid (tCA) and synthesized its conjugates with glutamic acid (tCA-GA) and aspartic acid (tCA-AA). We evaluated the anti-colitic activity of colon-targeted tCA using a dinitrobenzenesulfonic acid-induced rat colitis model. The conjugates lowered the distribut...