In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

• Hoofdauteurs: Benoît Bestgen (Auteur), Zakia Belaid-Choucair (Auteur), Thierry Lomberget (Auteur), Marc Le Borgne (Auteur), Odile Filhol (Auteur), Claude Cochet (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2017-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Protein kinase CK2 is a tetrameric holoenzyme composed of two catalytic (α and/or α') subunits and two regulatory (β) subunits. Crystallographic data paired with fluorescence imaging techniques have suggested that the formation of the CK2 holoenzyme complex within cells is a dynamic process. Al...