In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

• Main Authors: Benoît Bestgen (Author), Zakia Belaid-Choucair (Author), Thierry Lomberget (Author), Marc Le Borgne (Author), Odile Filhol (Author), Claude Cochet (Author)
• Format: Book
• Published: MDPI AG, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein kinase CK2 is a tetrameric holoenzyme composed of two catalytic (α and/or α') subunits and two regulatory (β) subunits. Crystallographic data paired with fluorescence imaging techniques have suggested that the formation of the CK2 holoenzyme complex within cells is a dynamic process. Al...