Endothelial <i>Adenosine Monophosphate-Activated Protein Kinase-Alpha1</i> Deficiency Potentiates Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension

• Autori principali: Ahmed Elsaie (Autore), Renuka T. Menon (Autore), Amrit K. Shrestha (Autore), Sharada H. Gowda (Autore), Nidhy P. Varghese (Autore), Roberto J. Barrios (Autore), Cynthia L. Blanco (Autore), Girija G. Konduri (Autore), Binoy Shivanna (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Bronchopulmonary dysplasia and pulmonary hypertension, or BPD-PH, are serious chronic lung disorders of prematurity, without curative therapies. Hyperoxia, a known causative factor of BPD-PH, activates adenosine monophosphate-activated protein kinase (AMPK) α1 in neonatal murine lungs; however, whet...