Mitapivat: New dawn in pyruvate kinase deficiency and beyond
Mitapivat is the first in class oral allosteric activator of pyruvate kinase enzyme, leading to increased ATP production. Since red blood cells (RBC) rely on anaerobic metabolism, converting phosphoenolpyruvate to pyruvate in Embden- Meyerhof glycolytic pathway is the most important step for ATP pro...
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Elsevier,
2024-06-01T00:00:00Z.
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