Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

• المؤلفون الرئيسيون: Ioannis Markakis (مؤلف), Ioannis Charitakis (مؤلف), Christine Beeton (مؤلف), Melpomeni Galani (مؤلف), Elpida Repousi (مؤلف), Stella Aggeloglou (مؤلف), Petros P. Sfikakis (مؤلف), Michael W. Pennington (مؤلف), K. George Chandy (مؤلف), Cornelia Poulopoulou (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evid...