Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

• Main Authors: Ioannis Markakis (Author), Ioannis Charitakis (Author), Christine Beeton (Author), Melpomeni Galani (Author), Elpida Repousi (Author), Stella Aggeloglou (Author), Petros P. Sfikakis (Author), Michael W. Pennington (Author), K. George Chandy (Author), Cornelia Poulopoulou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evid...