Tongluo Yishen Decoction Ameliorates Renal Fibrosis via NLRP3-Mediated Pyroptosis In Vivo and In Vitro

• Main Authors: Qi Jia (Author), Xiaoyu Zhang (Author), Gaimei Hao (Author), Yun Zhao (Author), Scott Lowe (Author), Lin Han (Author), Jianguo Qin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: In this study, we investigated the mechanism of Tongluo Yishen (TLYS) decoction in more detail, from the perspective of pyroptosis in the unilateral ureteral ligation (UUO) model and the hypoxia-induced renal tubular epithelial (NRK-52E) cell.Method: The UUO model was used, and after 14 day...