Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer

• Main Authors: Xiangqian Dong (Author), Yinghui Zhang (Author), Yang Sun (Author), Qiong Nan (Author), Maojuan Li (Author), Lanqing Ma (Author), Lei Zhang (Author), Juan Luo (Author), Yating Qi (Author), Yinglei Miao (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The human genome encodes more than 350 kinds of Krüppel-associated box (KRAB) domain-containing zinc-finger proteins (KZFPs), KRAB-type ZNF transcription factor family (KZNF) plays a vital role in gene regulatory networks. The KZNF family members include a large number of highly homologous...