The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria

• Main Authors: Daniel J. Watson (Author), Lizahn Laing (Author), Richard M. Beteck (Author), Liezl Gibhard (Author), Richard K. Haynes (Author), Lubbe Wiesner (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of Plasmodium falciparum (Pf) parasite strains tolerant of the artemisinin component and resistant to the other drug component in artemisinin combination therapies (ACTs) used for treatment now markedly complicates malaria control. Thus, development of new combination therapies are urg...