In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates

• Main Authors: Alessandro Giuliani (Author), Anna Giulia Balducci (Author), Elisa Zironi (Author), Gaia Colombo (Author), Fabrizio Bortolotti (Author), Luca Lorenzini (Author), Viola Galligioni (Author), Giampiero Pagliuca (Author), Alessandra Scagliarini (Author), Laura Calzà (Author), Fabio Sonvico (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nasal administration has been proposed as a potential approach for the delivery of drugs to the central nervous system. Ribavirin (RBV), an antiviral drug potentially useful to treat viral infections both in humans and animals, has been previously demonstrated to attain several brain compartments af...