Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

• Main Authors: Lingling Ye (Author), Xiang You (Author), Jie Zhou (Author), Chaohui Wu (Author), Meng Ke (Author), Wanhong Wu (Author), Pinfang Huang (Author), Cuihong Lin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Objective: Daptomycin is used to treat Gram-positive infections in adults and children and its dosing varies among different age groups. We focused on the pharmacokinetics of daptomycin in children with renal impairment, which has not been evaluated.Methods: A physiologically based ph...