Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

• Main Authors: Carolina Nunes (Author), Susana Proença (Author), Giovanna Ambrosini (Author), David Pamies (Author), Aurélien Thomas (Author), Nynke I. Kramer (Author), Marie-Gabrielle Zurich (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For ethical, economical, and scientific reasons, animal experimentation, used to evaluate the potential neurotoxicity of chemicals before their release in the market, needs to be replaced by new approach methodologies. To illustrate the use of new approach methodologies, the human induced pluripoten...