The Structural Understanding of Transthyretin Misfolding and the Inspired Drug Approaches for the Treatment of Heart Failure Associated With Transthyretin Amyloidosis

• Main Authors: Shan He (Author), Xinyue He (Author), Lei Liu (Author), Wenbo Zhang (Author), Lanlan Yu (Author), Zhun Deng (Author), Zhang Feiyi (Author), Shanshan Mo (Author), Yue Fan (Author), Xinyue Zhao (Author), Lun Wang (Author), Chenxuan Wang (Author), Shuyang Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Substantial controversies exist in the exploration of the molecular mechanism of heart failure (HF) and pose challenges to the diagnosis of HF and the discovery of specific drugs for the treatment. Recently, cardiac transthyretin (TTR) amyloidosis is becoming recognized as one of major causes of und...