Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds

• Main Authors: Bruno Rizzuti (Author), Laura Ceballos-Laita (Author), David Ortega-Alarcon (Author), Ana Jimenez-Alesanco (Author), Sonia Vega (Author), Fedora Grande (Author), Filomena Conforti (Author), Olga Abian (Author), Adrian Velazquez-Campoy (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibiting the main protease 3CLpro is the most common strategy in the search for antiviral drugs to fight the infection from SARS-CoV-2. We report that the natural compound eugenol is able to hamper in vitro the enzymatic activity of 3CLpro, the SARS-CoV-2 main protease, with an inhibition constant...