Thiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice

• Autors principals: K. Esparza (Autor), S. D. Oliveira (Autor), M. Castellon (Autor), R. D. Minshall (Autor), H. Onyuksel (Autor)
• Format: Llibre
• Publicat: Hindawi Limited, 2023-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Sepsis is a life-threatening clinical condition caused by infection and transposition of pathogens and pathogen-associated molecular patterns (PAMPs) into the host bloodstream. During sepsis, activation of toll-like receptors (TLRs) on immune cells triggers the release of pro-inflammatory cytokines...