Thiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice

• Egile Nagusiak: K. Esparza (Egilea), S. D. Oliveira (Egilea), M. Castellon (Egilea), R. D. Minshall (Egilea), H. Onyuksel (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2023-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Sepsis is a life-threatening clinical condition caused by infection and transposition of pathogens and pathogen-associated molecular patterns (PAMPs) into the host bloodstream. During sepsis, activation of toll-like receptors (TLRs) on immune cells triggers the release of pro-inflammatory cytokines...