Thiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice

• Main Authors: K. Esparza (Author), S. D. Oliveira (Author), M. Castellon (Author), R. D. Minshall (Author), H. Onyuksel (Author)
• Formato: Libro
• Publicado: Hindawi Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Sepsis is a life-threatening clinical condition caused by infection and transposition of pathogens and pathogen-associated molecular patterns (PAMPs) into the host bloodstream. During sepsis, activation of toll-like receptors (TLRs) on immune cells triggers the release of pro-inflammatory cytokines...