Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

• Main Authors: Ilaria Coppola (Author), Bas Brouwers (Author), Leanne Walker (Author), Ceyhun Alar (Author), Sandra Meulemans (Author), Anne White (Author), Bruno Ramos-Molina (Author), John W.M. Creemers (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent association of polymorphisms in the proprotein convertase FURIN with type 2 d...