Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

• मुख्य लेखकों: Ilaria Coppola (लेखक), Bas Brouwers (लेखक), Leanne Walker (लेखक), Ceyhun Alar (लेखक), Sandra Meulemans (लेखक), Anne White (लेखक), Bruno Ramos-Molina (लेखक), John W.M. Creemers (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent association of polymorphisms in the proprotein convertase FURIN with type 2 d...