Genotype-phenotype association and biochemical analyses of glucose-6-phosphate dehydrogenase variants: Implications for the hemolytic risk of using 8-aminoquinolines for radical cure

• Main Authors: Sirapapha Sudsumrit (Author), Kamonwan Chamchoy (Author), Duantida Songdej (Author), Poom Adisakwattana (Author), Srivicha Krudsood (Author), Emily R. Adams (Author), Mallika Imwong (Author), Ubolsree Leartsakulpanich (Author), Usa Boonyuen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background:Plasmodium vivax remains the malaria species posing a major threat to human health worldwide owing to its relapse mechanism. Currently, the only drugs of choice for radical cure are the 8-aminoquinolines (primaquine and tafenoquine), which are capable of killing hypnozoites and thus preve...