Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma

• Main Authors: Kyung Duk Koh (Author), Luke R. Bonser (Author), Walter L. Eckalbar (Author), Ofer Yizhar-Barnea (Author), Jiangshan Shen (Author), Xiaoning Zeng (Author), Kirsten L. Hargett (Author), Dingyuan I. Sun (Author), Lorna T. Zlock (Author), Walter E. Finkbeiner (Author), Nadav Ahituv (Author), David J. Erle (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive regulatory elements in bronchial epithelial cells and used these data to develop a CRISPR interference (CRISPRi)-based th...