Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.

• Main Authors: Shamila S Gunatilleke (Author), Claudia M Calvet (Author), Jonathan B Johnston (Author), Chiung-Kuang Chen (Author), Grigori Erenburg (Author), Jiri Gut (Author), Juan C Engel (Author), Kenny K H Ang (Author), Joseph Mulvaney (Author), Steven Chen (Author), Michelle R Arkin (Author), James H McKerrow (Author), Larissa M Podust (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due to heart failure, as well as inflicting a heavy ec...