Rational design of a genome‐based insulated system in Escherichia coli facilitates heterologous uricase expression for hyperuricemia treatment

• Main Authors: Lina He (Author), Wei Tang (Author), Ling Huang (Author), Wei Zhou (Author), Shaojia Huang (Author), Linxuan Zou (Author), Lisha Yuan (Author), Dong Men (Author), Shiyun Chen (Author), Yangbo Hu (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Hyperuricemia is a prevalent disease worldwide that is characterized by elevated urate levels in the blood owing to purine metabolic disorders, which can result in gout and comorbidities. To facilitate the treatment of hyperuricemia through the uricolysis, we engineered a probiotic Escheric...