Prospective Prediction of Dapaconazole Clinical Drug-Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling

Prospective Prediction of Dapaconazole Clinical Drug-Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling

This study predicted dapaconazole clinical drug-drug interactions (DDIs) over the main Cytochrome P450 (CYP) isoenzymes using static (in vitro to in vivo extrapolation equation, IVIVE) and dynamic (PBPK model) approaches. The in vitro inhibition of main CYP450 isoenzymes by dapaconazole in a human l...

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Main Authors: Natalícia de Jesus Antunes (Author), Fernanda de Lima Moreira (Author), Karin Kipper (Author), Lewis Couchman (Author), Daniel Temponi Lebre (Author), Atholl Johnston (Author), Gilberto De Nucci (Author)
Format: Book
Published: MDPI AG, 2022-12-01T00:00:00Z.
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