Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

• Päätekijät: Zhiwei Zheng (Tekijä), Benyu Nan (Tekijä), Chang Liu (Tekijä), Dongmei Tang (Tekijä), Wen Li (Tekijä), Liping Zhao (Tekijä), Guohui Nie (Tekijä), Yingzi He (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

This study aimed to evaluate the therapeutic potential of inhibiting protein arginine methyltransferase 5 (PRMT5) in cisplatin-induced hearing loss. The effects of PRMT5 inhibition on cisplatin-induced auditory injury were determined using immunohistochemistry, apoptosis assays, and auditory brainst...