Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

• Main Authors: Joost Verbeek (Author), Jonas Eriksson (Author), Stina Syvänen (Author), Marc Huisman (Author), Robert C. Schuit (Author), Carla F. M. Molthoff (Author), Rob A. Voskuyl (Author), Elizabeth C. de Lange (Author), Adriaan A. Lammertsma (Author), Albert D. Windhorst (Author)
• Format: Book
• Published: SpringerOpen, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Several P-glycoprotein (P-gp) substrate tracers are available to assess P-gp function in vivo, but attempts to develop a tracer for measuring expression levels of P-gp have not been successful. Recently, (Z)-2-(5-fluoro-2-oxoindolin-3-ylidene)-N-(4-methoxyphenyl)hydrazine-carboth...