Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling

Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling

Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders. This study evaluated the effect of the macrolide antibiotic azithromycin (AZM) on oxidat...

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Main Authors: Emad H. M. Hassanein (Author), Ghadir A. Sayed (Author), Abdullah M. Alzoghaibi (Author), Abdalmohsen S. Alammar (Author), Basel A. Abdel-Wahab (Author), Omnia A. M. Abd El-Ghafar (Author), Somya E. Mahdi (Author), Ahmed M. Atwa (Author), Mohammed A. Alzoghaibi (Author), Ayman M. Mahmoud (Author)
Format: Book
Published: MDPI AG, 2022-12-01T00:00:00Z.
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