Genetic polymorphisms associated to folate transport as predictors of increased risk for acute lymphoblastic leukemia in Mexican children

• Main Authors: Fausto Zaruma-Torres (Author), Ismael Lares-Asseff (Author), Verónica Loera-Castañeda (Author), Aurea Lima (Author), Aarón Reyes-Espinoza (Author), Martha Sosa-Macías (Author), Carlos Galaviz-Hernández (Author), María Cristina Arias-Pelaez (Author), Miguel Angel Reyes-López (Author), Luis Abel Quiñones (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute lymphoblastic leukemia (ALL) is a frequent neoplasia occurring in children. The most commonly used drug for the treatment of ALL is methotrexate (MTX), an anti-folate agent. Previous studies suggest that folate transporters play a role in ALL prognosis and that genetic polymorphism of genes en...