Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species

• Main Authors: Blanca Cucarull (Author), Anna Tutusaus (Author), Tania Hernáez-Alsina (Author), Pablo García de Frutos (Author), María Reig (Author), Anna Colell (Author), Montserrat Marí (Author), Albert Morales (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment. Antioxidant supplements are becoming popular additions to our diet, particularly glutathione derivativ...