Lymphangiogenesis and angiogenesis rescue murine ischemic hindlimb via transient receptor potential vanilloid 4

• Main Authors: Hideaki Yamada (Author), Naoaki Sakata (Author), Tomoko Tanaka (Author), Hideaki Tagashira (Author), Gumpei Yoshimatsu (Author), Ryo Kawakami (Author), Hideichi Wada (Author), Takahiro Iwamoto (Author), Shohta Kodama (Author)
• Format: Book
• Published: Elsevier, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we assessed the regulation of transient receptor potential vanilloid 4 (TRPV4) promoting lymphangio/angiogenesis to improve the ischemic hindlimb animal model, and revealed that (1) a TRPV4 agonist improved the blood flow of ischemic hindlimbs by inducing both angiogenesis and lymphan...