Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo

• Main Authors: Yuan-Qing Qu (Author), Lin-Lin Song (Author), Su-Wei Xu (Author), Margaret Sum Yee Yu (Author), Onat Kadioglu (Author), Francesco Michelangeli (Author), Betty Yuen Kwan Law (Author), Thomas Efferth (Author), Christopher Wai-Kei Lam (Author), Vincent Kam Wai Wong (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug resistance in cancer has been classified as innate resistance or acquired resistance, which were characterized by apoptotic defects and ABC transporters overexpression respectively. Therefore, to preclude or reverse these resistance mechanisms could be a promising strategy to improve chemothera...