Induction of apoptosis by Oleracein A and Oleracein B in HepG2 cancerous cells is mediated by ceramide generation, caspase-9/caspase-3 pathway activation, and oxidative damage

• Ngā kaituhi matua: Hamidreza Khodajou-Masouleh (Author), Masoud Mashhadi Akbar Boojar (Author), Sarah Khavari-Nejad (Author), Gilda Karimi (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2022-03-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The present study aimed to discover whether oleracein A (OA) and oleracein B (OB) have anti-proliferative effects on HepG2 cell line and, if so, by which mechanisms they exert their effects. The results demonstrate that both OA and OB are independently able to decrease the viability of HepG2 cells i...