Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway

• Main Authors: Ravishankar Chandrasekaran (Author), Carolyn R. Morris (Author), Isabella M. Butzirus (Author), Zoe F. Mark (Author), Amit Kumar (Author), Dhemerson Souza De Lima (Author), Nirav Daphtary (Author), Minara Aliyeva (Author), Matthew E. Poynter (Author), Vikas Anathy (Author), Anne E. Dixon (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is a risk factor for severe influenza, and asthma exacerbations caused by respiratory viral infections. We investigated mechanisms that increase the severity of airway disease related to influenza in obesity using cells derived from obese and lean individuals, and in vitro and in vivo models...