The effect of mAb and excipient cryoconcentration on long-term frozen storage stability - part 2: Aggregate formation and oxidation

• المؤلفون الرئيسيون: Oliver Bluemel (مؤلف), Jakob W. Buecheler (مؤلف), Astrid Hauptmann (مؤلف), Georg Hoelzl (مؤلف), Karoline Bechtold-Peters (مؤلف), Wolfgang Friess (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

We examined the impact of monoclonal antibody (mAb) and buffer concentration, mimicking the cryoconcentration found upon freezing in a 2 L bottle, on mAb stability during frozen storage. Upon cryoconcentration, larger protein molecules and small excipient molecules freeze-concentrate differently, re...