Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization

• Main Authors: María Pimentel-Santillana (Author), Paqui G. Través (Author), Raquel Pérez-Sen (Author), Esmerilda G. Delicado (Author), Paloma Martín-Sanz (Author), María Teresa Miras-Portugal (Author), Lisardo Boscá (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The nucleotide uridine trisphosphate (UTP) released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y). P2Y receptors are G protein-coupled receptors expressed in many cell types. These receptors mediate several cell responses and they are...