Anti-RANKL Inhibits Thymic Function and Causes DRONJ in Mice

• Main Authors: Yusuke Nakamura (Author), Takashi Kikuiri (Author), Takahiro Sugiyama (Author), Ayako Maeda (Author), Daisuke Izumiyama (Author), Daigo Yahata (Author), Yoshitaka Yoshimura (Author), Tetsuo Shirakawa (Author), Yoshimasa Kitagawa (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Denosumab, a human monoclonal antibody against receptor activator of nuclear factor-kappa B ligand (RANKL), is a novel bone antiresorptive agent used in patients with osteoporosis or metastatic bone cancer. Denosumab-related osteonecrosis of the jaw (DRONJ) has been recently reported in...