Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

• Κύριοι συγγραφείς: Christopher Rowbottom (Συγγραφέας), Alicia Pietrasiewicz (Συγγραφέας), Taras Tuczewycz (Συγγραφέας), Richard Grater (Συγγραφέας), Daniel Qiu (Συγγραφέας), Sudarshan Kapadnis (Συγγραφέας), Patrick Trapa (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2021-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the impact of transporters in vivo invol...