Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

• Main Authors: Paula I. Moreira (Author), Gemma Casadesus (Author), Mark A. Smith (Author), George Perry (Author), Hyoung-Gon Lee (Author), Cristina Carvalho (Author), Xiongwei Zhu (Author), Sonia Correia (Author), Susana Cardoso (Author), Renato Santos (Author)
• Format: Book
• Published: MDPI AG, 2009-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been est...