The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

• Hoofdauteurs: Tomas Smutny (Auteur), Jan Dusek (Auteur), Lucie Hyrsova (Auteur), Jana Nekvindova (Auteur), Alzbeta Horvatova (Auteur), Stanislav Micuda (Auteur), Sabine Gerbal-Chaloin (Auteur), Petr Pavek (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level. We examined the involvement of the 3'-untranslate...