The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

• Main Authors: Tomas Smutny (Author), Jan Dusek (Author), Lucie Hyrsova (Author), Jana Nekvindova (Author), Alzbeta Horvatova (Author), Stanislav Micuda (Author), Sabine Gerbal-Chaloin (Author), Petr Pavek (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level. We examined the involvement of the 3'-untranslate...