Self-assembled tetrahedral framework nucleic acid mediates tumor-associated macrophage reprogramming and restores antitumor immunity

• Main Authors: Husun Qian (Author), Ting Zhou (Author), Yixin Fu (Author), Minkang Guo (Author), Wu Yang (Author), Dian Zhang (Author), Wenli Fang (Author), Mengli Yao (Author), He Shi (Author), Chengsen Chai (Author), Wei Cheng (Author), Shijia Ding (Author), Tingmei Chen (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is increasing interest in depleting or repolarizing tumor-associated macrophages (TAMs) to generate a proinflammatory effect. However, TAMs usually display an immunosuppressive M2-like phenotype in the tumor microenvironment. Apparently, developing a macrophage-targeting delivery system with i...