Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis

• Main Authors: Juan Rong (Author), Chenxia Han (Author), Yan Huang (Author), Yiqin Wang (Author), Qi Qiu (Author), Manjiangcuo Wang (Author), Shisheng Wang (Author), Rui Wang (Author), Juqin Yang (Author), Xia Li (Author), Chenggong Hu (Author), Zhiyao Chen (Author), Lihui Deng (Author), Wei Huang (Author), Qing Xia (Author), Dan Du (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options. Although inhibiting xanthine oxidase (XO) in the treatment of AP has been studied in several experimental models and clinical trials, whether XO is a target of AP and what its the main mechanism of action is...