A frequent CYP2D6 variant promotes skipping of exon 3 and reduces CYP2D6 protein expression in human liver samples

• Principais autores: Joseph M. Collins (Autor), Hannah Lester (Autor), Samia Shabnaz (Autor), Danxin Wang (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

CYP2D6 is one of the most polymorphic drug-metabolizing enzymes in the liver. While genetic CYP2D6 variants serve as clinical biomarkers to predict CYP2D6 activity, large inter-person variability in CYP2D6 expression remains unaccounted for. Previous results suggest that there is variable expression...