Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

• Main Authors: Alejandra Bosco (Author), Cesar O. Romero (Author), Kevin T. Breen (Author), Alexis A. Chagovetz (Author), Michael R. Steele (Author), Balamurali K. Ambati (Author), Monica L. Vetter (Author)
• Format: Book
• Published: The Company of Biologists, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus paralleled by local microgliosis and microglia activation, which begin at early stages of the disease. However, the possibi...