Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine1

• Main Authors: Niccolò Chiaramonte (Author), Soumia Maach (Author), Caterina Biliotti (Author), Andrea Angeli (Author), Gianluca Bartolucci (Author), Laura Braconi (Author), Silvia Dei (Author), Elisabetta Teodori (Author), Claudiu T. Supuran (Author), Maria Novella Romanelli (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Carbonic Anhydrase (CA, EC 4.2.1.1) activating properties of histamine have been known for a long time. This compound has been extensively modified but only in few instances the imidazole ring has been replaced with other heterocycles. It was envisaged that the imidazoline ring could be a bioiso...